The domestic large-scale diabetes API production line was put into production in Linuo, with an annual output of 6,000 tons
[China Pharmaceutical Network Industry News] With an annual output of 6,000 tons, the production capacity ranks among the top five in the world! On September 23, my country's largest metformin hydrochloride project was completed and put into production in Linuo Keyuan Pharmaceutical. It is understood that metformin hydrochloride is the most widely used API for oral anti-diabetic drugs in the world, with an annual global demand for APIs of nearly 40,000 tons. The completion of the project will further consolidate my country's leading edge in this field.
Improving the supply quality of APIs is the main direction of supply-side reform to improve drug quality, and comprehensively improving the quality of products and services is an important task for deepening the implementation of the "Healthy China" strategy. According to the requirements of "Made in China 2025", the project adheres to the principles of "innovation-driven, quality-first, green development" and "frontier, leading, and intelligent", and carries out construction from a high starting point, with distinctive features and outstanding advantages. First, software and hardware such as equipment, systems, and control valves are all sourced from internationally renowned manufacturers such as Siemens, Baode, and Spirax Sarco. Second, the project uses 6,000 liters of glass-lined drying double cones for the first time, which is currently the largest specification for glass-lined glass lining in the pharmaceutical industry in China. The third is the high degree of automation. From the pumping of raw materials to synthesis, refining, to inspection, subcontracting, and storage, intelligent production is realized. In particular, the automatic PE bag packaging line has become the only project in China that realizes the automatic packaging function of two-layer PE bags. Fourth, the solvent recovery system adopts continuous distillation design, automatic control, and the recovery rate is increased to more than 90%, which saves 30% of energy compared with the traditional method.
According to the diabetes survey data released by the International Diabetes Federation (IDF), the number of people with diabetes in the world accounts for 5.80% of the global population. 350 million people are potentially at high risk of developing diabetes. The number of diabetic patients in China is close to 118 million, ranking first in the world. According to the current development trend, it is estimated that by 2040, the number of diabetic patients in China will reach 150 million. With the aging of the population and the younger diabetic patients, the market demand for metformin hydrochloride will maintain a growth rate of more than 7% in the next 20 years. The completion of this project will effectively alleviate the tight supply of raw materials in the market.
The project is located in Yuhuangmiao Town, Shanghe County, Shandong Province. Yuhuangmiao Town is the second batch of characteristic "glass towns" recognized in my country, and it is also the first national characteristic town approved by Jinan, the capital city of Shandong Province. The completion of the 6,000-ton metformin project will further accelerate the transformation of local new and old kinetic energy, promote industrial transformation and upgrading, accelerate the release of industrial dividends, and make development advantages more obvious.
On the same day, the foundation stone was laid for the Linuo Keyuan Pharmaceutical and Ropivacaine Hydrochloride Integrated Production Line Project.
Relevant information:
6000t/a Metformin Hydrochloride Project Introduction
The 6000t/a metformin hydrochloride project is currently the largest single-batch metformin hydrochloride production line in China. The project started to break ground in July 2016, a test run was successful in May 2017, and it was officially put into production in August 2017.
Combining with the national strategic goal of "innovation-driven, quality-first, green development" proposed by "Made in China 2025", the project follows the "New Four Modernizations" concept of Linuo Group, and is designed and constructed in accordance with international GMP and FDA certification standards.
The software and hardware of the project adopts international advanced and domestic first-class systems and equipment: Siemens PCS7 system is used for automatic control, and there are 2047 DCS detection points. The brand provides a strong guarantee for the operation and maintenance of the entire system in the later stage. It is the first time that the equipment adopts an integrated filter and washing machine, which is currently the largest specification used in the pharmaceutical industry in China. The equipment is changed from the traditional manual transfer and feeding of materials to beating and then conveying the solid-liquid state materials through the pipeline, without the need for open operation. , save labor, and improve the production environment; the drying double cone is also the largest specification for lining glass lined in the pharmaceutical industry in China, which meets the needs of the largest single batch production and avoids the quality risk caused by mixed batches in small batches; solvent recovery The system adopts continuous distillation design. Through automatic control, the recovery rate can be increased to more than 90%, and the quality of the recovered solvent will be better than that of simple distillation; the finished product adopts an automatic packaging system, which is designed by Harbin Institute of Technology Robot Group. Processing, installation, is currently the only domestic two-layer PE bag to achieve automatic packaging function at the same time. The equipment selection and process design of the entire metformin hydrochloride production line, from the pumping of raw materials, to synthesis, refining, to inspection, subcontracting, and storage, all realize intelligent production.
In addition, the VOC treatment facilities of the project are demonstrated and designed in accordance with the current highest domestic standard requirements, combined with the composition and properties of the gas generated during the production process, including water spray absorption, activated carbon adsorption, UV photolysis and other treatment measures to ensure that gas emissions are safe. Compliance, escort the normal operation of the overall production line.
The 6000t/a metformin hydrochloride production line has been put into use and has reached the domestic first-class and international advanced level. It will provide high-quality old products and lay a solid foundation for Keyuan Pharmaceutical to go international.
Ropivacaine hydrochloride comprehensive production line project introduction:
The "Healthy China 2030" Planning Outline pointed out that the next 15 years will be an important period of strategic opportunity to promote the construction of a healthy China. When "Healthy China" has become a national development strategy, Keyuan Pharma is responsible for the quality supply and optimization of API products. The foundation stone laying ceremony of the isoproterenol hydrochloride comprehensive production line project, from the inside to the outside, escorts the health.
The total investment of the ropivacaine hydrochloride comprehensive production line project is about 66 million yuan, covering an area of 1620 square meters and a building area of 5600 square meters. The project was approved in June 2017. The designed production capacity: ropivacaine 5 tons/year, anesthesia drug for surgery; lansoprazole 10 tons/year, drug for gastric ulcer treatment; fluoxetine hydrochloride 7 tons/year, antidepressant Drugs; isoproterenol hydrochloride 1 ton/year, a drug for the treatment of cardiogenic or septic shock.
The project adopts the most authoritative design concept to design, fully integrates automation and informatization, adopts DCS control system, more than 2,500 automatic control points, and 194 sets of new equipment, all of which are first-line brands at home and abroad. After the project is constructed, it will become a domestic advanced A demonstration factory for intelligent manufacturing of APIs. This project is another expansion project of Keyuan Pharmaceutical after the construction of the 6000t/a metformin hydrochloride project.
Original title: China's largest diabetes API production line was put into production in Linuo Author: Xin Mingrui
(Source: Volkswagen Network)
